Transfusion support for a woman with RHD*09.01.02 and the novel RHD*01W.161 allele in trans.

ABSTRACT: According to recent work group recommendations, individuals with the serologic weak D phenotypes should be RHD genotyped and individuals with molecular weak D types 1, 2, 3, 4.0, or 4.1 should be treated as D+. We report an African American woman with a long-standing history of metrorrhagia, who presented for infertility evaluation. Blood grouping showed AB with a possible subgroup of A, based on mixed-field agglutination, and a serologic weak D phenotype. Results from routine red cell genotyping for the RHD gene was incongruent with the serologic RhCE phenotype. For the surgical procedure, the patient was hence scheduled to receive group AB, D- RBC transfusions. Subsequent molecular analysis identified the ABO*A2.01 and ABO*B.01 alleles for the ABO genot

SUBMITTER: Srivastava K 

PROVIDER: S-EPMC9364384 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature