Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice.

ABSTRACT: Alcohol consumption is a global healthcare problem with enormous social, economic, and clinical consequences. The liver sustains the earliest and the greatest degree of tissue injury due to chronic alcohol consumption and it has been estimated that alcoholic liver disease (ALD) accounts for almost 50% of all deaths from cirrhosis in the world. In this study, we used a modified Lieber-DeCarli (LD) diet to treat mice with alcohol and simulate chronic alcohol drinking. Using an untargeted metabolomics approach, our aim was to identify the various metabolites and pathways that are altered in the early stages of ALD. Histopathology showed minimal changes in the liver after 6 weeks of alcohol consumption. However, untargeted metabolomics analyses identified 304 metabolic features that were eithe

SUBMITTER: Charkoftaki G 

PROVIDER: S-EPMC9364420 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature