Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold.

ABSTRACT: The protein kinase family is characterized by substantial conservation of architectural elements that are required for both ATP binding and phosphotransferase activity. Many of these structural features have also been identified in homologous enzymes that phosphorylate a variety of alternative, non-protein substrates. A comparative structural analysis of these different kinase sub-classes is a portal to a greater understanding of reaction mechanisms, enzyme regulation, inhibitor-development strategies, and superfamily-level evolutionary relationships. To serve such advances, we review structural elements of the protein kinase fold that are conserved in the subfamily of inositol phosphate kinases (InsPKs) that share a PxxxDxKxG catalytic signature: inositol 1,4,5-trisphosphate kinase (IP3K)

SUBMITTER: Shears SB 

PROVIDER: S-EPMC9364425 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature