The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice.

ABSTRACT:

Background

Air pollution has been associated with neurodevelopmental disorders in epidemiological studies. In our studies in mice, developmental exposures to ambient ultrafine particulate (UFP) matter either postnatally or gestationally results in neurotoxic consequences that include brain metal dyshomeostasis, including significant increases in brain Fe. Since Fe is redox active and neurotoxic to brain in excess, this study examined the extent to which postnatal Fe inhalation exposure, might contribute to the observed neurotoxicity of UFPs. Mice were exposed to 1 µg/m³ Fe oxide nanoparticles alone, or in conjunction with sulfur dioxide (Fe (1 µg/m³) + SO₂ (SO₂ at 1.31 mg/m³, 500 ppb) from postnatal days 4-7 and 10-13 for 4 h/d

SUBMITTER: Sobolewski M 

PROVIDER: S-EPMC9364598 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature