Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1^G93A ALS mouse model.

ABSTRACT:

Background

Evidences indicate that inflammasome compounds participate in amyotrophic lateral sclerosis (ALS), a fatal progressive motoneuron degenerative disease. Researchers have observed the expressions of nucleotide oligomerization domain (NOD)-like receptor protein 3 (NLRP3) related inflammasome components in specific regions of the central nervous system in different ALS models, but the cellular spatiotemporal evolution of this canonical inflammasome pathway and pyroptosis during ALS progression are unclear.

Methods

The spinal cords of hSOD1^G93A mice (ALS mice) and age-matched littermates (CON mice) were dissected at pre-symptomatic stage (60 d), early- symptomatic stage (95 d), symptomatic stage (108 d) and late-symptomatic stage (122 d) of the disease. By u

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9364624 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature