The association of ACE I/D polymorphism with the severity of COVID-19 in Iranian patients: A case-control study.

ABSTRACT:

Background

Since the beginning of the COVID-19 pandemic, researchers have tried to find the reason behind the variety of the symptoms and disease severity among patients. It seems that genetic background may contribute in severity of this infection. The renin-angiotensin system (RAS) is involved in the pathogenesis of COVID-19. An Insertion/Deletion (I/D) polymorphism in the ACE1 gene may explain the genetic risk for disease severity.

Methods

We genotyped 251 COVID-19 patients: 151 patients with mild or asymptomatic disease compared with 100 patients with severe to critical illness (without any comorbidities for the disease severity).

Results

There was a significant association between the ACE1 DD genotype and disease severity (p-value = 1 × 10^-2; OR

SUBMITTER: Soltani Rezaiezadeh J 

PROVIDER: S-EPMC9364667 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature