Spatial multi-omic map of human myocardial infarction.

ABSTRACT: Myocardial infarction is a leading cause of death worldwide¹. Although advances have been made in acute treatment, an incomplete understanding of remodelling processes has limited the effectiveness of therapies to reduce late-stage mortality². Here we generate an integrative high-resolution map of human cardiac remodelling after myocardial infarction using single-cell gene expression, chromatin accessibility and spatial transcriptomic profiling of multiple physiological zones at distinct time points in myocardium from patients with myocardial infarction and controls. Multi-modal data integration enabled us to evaluate cardiac cell-type compositions at increased resolution, yielding insights into changes of the cardiac transcriptome and epigenome through the identifica

SUBMITTER: Kuppe C 

PROVIDER: S-EPMC9364862 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature