Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure.

ABSTRACT: Heart failure represents a major cause of morbidity and mortality worldwide. Single-cell transcriptomics have revolutionized our understanding of cell composition and associated gene expression. Through integrated analysis of single-cell and single-nucleus RNA-sequencing data generated from 27 healthy donors and 18 individuals with dilated cardiomyopathy, here we define the cell composition of the healthy and failing human heart. We identify cell-specific transcriptional signatures associated with age and heart failure and reveal the emergence of disease-associated cell states. Notably, cardiomyocytes converge toward common disease-associated cell states, whereas fibroblasts and myeloid cells undergo dramatic diversification. Endothelial cells and pericytes display global transcriptional s

SUBMITTER: Koenig AL 

PROVIDER: S-EPMC9364913 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature