Dataset Information
Immunogenicity and safety of a RBD vaccine against SARS-CoV-2 in a murine model.
Ontology highlight
ABSTRACT: Introduction
Although more than half of the world's population is already vaccinated, the appearance of new variants of concern puts public health at risk due to the generation of new immunogens against the virus as a crucial and relevant strategy in the control of these new variants.Methods
A preclinical study used a potential vaccine candidate (RBD, SARS-CoV-2). Four groups of BALB/c mice were used, a control group, an adjuvant group, a group inoculated with one dose of RBD subunit protein, and the fourth group inoculated with two doses of RBD subunit protein.Results
No inflammatory or cellular changes were shown in the mice's anatomopathological evaluation. Higher kinetics and 75% seroconversion were obtained in the mice inoculated with two doses of RBD (P < 0.0001).Conclusions
The application of two doses of the RBD vaccine candidate in BALB/c mice proved safe and immunogenic against SARS-CoV-2.
SUBMITTER: Diaz A
PROVIDER: S-EPMC9364943 | biostudies-literature | 2022 Sep-Oct
REPOSITORIES: biostudies-literature
Publications
Immunogenicity and safety of a RBD vaccine against SARS-CoV-2 in a murine model.
Travel medicine and infectious disease 20220810
<h4>Introduction</h4>Although more than half of the world's population is already vaccinated, the appearance of new variants of concern puts public health at risk due to the generation of new immunogens against the virus as a crucial and relevant strategy in the control of these new variants.<h4>Methods</h4>A preclinical study used a potential vaccine candidate (RBD, SARS-CoV-2). Four groups of BALB/c mice were used, a control group, an adjuvant group, a group inoculated with one dose of RBD sub ...[more]
