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Diastereoselective additions of H-phosphinates to alkenyl ketones under phase-transfer conditions.

ABSTRACT: Additions of bulky H-phosphinates to β,β-disubstituted alkenyl ketones under the action of a phase transfer-catalyst led to a new class of carbon quaternary center-containing phosphinates with unprecedented control of the relative configuration of the adjacent carbon and phosphorous chiral centers with high diastereoselectivity in most cases.

SUBMITTER: Yadavalli KP

PROVIDER: S-EPMC9365031 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Diastereoselective additions of H-phosphinates to alkenyl ketones under phase-transfer conditions.

Yadavalli Krishna P KP Cummines Johannah E JE Carlisle Chace J CJ Lepore Salvatore D SD

Chemical communications (Cambridge, England) 20220530 44

Additions of bulky H-phosphinates to β,β-disubstituted alkenyl ketones under the action of a phase transfer-catalyst led to a new class of carbon quaternary center-containing phosphinates with unprecedented control of the relative configuration of the adjacent carbon and phosphorous chiral centers with high diastereoselectivity in most cases. ...[more]

PMID: 35548924

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