The rippled β-sheet layer configuration-a novel supramolecular architecture based on predictions by Pauling and Corey.

ABSTRACT: The rippled β-sheet is a peptidic structural motif related to but distinct from the pleated β-sheet. Both motifs were predicted in the 1950s by Pauling and Corey. The pleated β-sheet was since observed in countless proteins and peptides and is considered common textbook knowledge. Conversely, the rippled β-sheet only gained a meaningful experimental foundation in the past decade, and the first crystal structural study of rippled β-sheets was published as recently as this year. Noteworthy, the crystallized assembly stopped at the rippled β-dimer stage. It did not form the extended, periodic rippled β-sheet layer topography hypothesized by Pauling and Corey, thus calling the validity of their prediction into question. NMR work conducted since moreover shows that certain model peptides rather

SUBMITTER: Hazari A 

PROVIDER: S-EPMC9365095 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature