A theory of coalescence of signaling receptor clusters in immune cells.

ABSTRACT: A theory of coalescence of signal receptor clusters in mast cells is developed in close connection with experiments. It is based on general considerations involving a feedback procedure and a time-dependent capture as part of a reaction-diffusion process. Characteristic features of observations that need to be explained are indicated and it is shown why calculations available in the literature are not satisfactory. While the latter involves static centers at which the reaction part of the phenomenon occurs, by its very nature, coalescence involves dynamically evolving centers. This is so because the process continuously modifies the size of the cluster aggregate which then proceeds to capture more material. We develop a procedure that consists of first solving a static reaction-diff

SUBMITTER: Kenkre VM 

PROVIDER: S-EPMC9365117 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature