IGFBP5 is Upregulated and Associated with Poor Prognosis in Colorectal Cancer.

ABSTRACT:

Purpose

This study aimed to investigate the role of IGFBP5 in colorectal cancer (CRC) and the relationship between the expression of IGFBP5 and clinicopathological parameters in CRC patients.

Patients and methods

Immunohistochemical analysis was used to detect the expression of IGFBP5 and its correlation with clinicopathological parameters of CRC patients. Prognosis analysis, gene set enrichment analysis, and protein interaction network analysis were performed using bioinformatics analysis. The Genomics of Drug Sensitivity in Cancer (GDSC) dataset was used to analyze the correlation between the expression of IGFBP5 and drug resistance.

Results

Immunohistochemical analysis revealed that the expression of IGFBP5 was significantly higher in CRC tissues than in para-cance

SUBMITTER: Deng Y 

PROVIDER: S-EPMC9365118 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature