Dichotomous Roles of Smooth Muscle Cell-Derived MCP1 (Monocyte Chemoattractant Protein 1) in Development of Atherosclerosis.

ABSTRACT:

Background

Smooth muscle cells (SMCs) in atherosclerotic plaque take on multiple nonclassical phenotypes that may affect plaque stability and, therefore, the likelihood of myocardial infarction or stroke. However, the mechanisms by which these cells affect stability are only beginning to be explored.

Methods

In this study, we investigated the contribution of inflammatory MCP1 (monocyte chemoattractant protein 1) produced by both classical Myh11 (myosin heavy chain 11)⁺ SMCs and SMCs that have transitioned through an Lgals3 (galectin 3)⁺ state in atherosclerosis using smooth muscle lineage tracing mice that label all Myh11⁺ cells and a dual lineage tracing system that targets Lgals3-transitioned SMC only.

Results

We show that loss of MC

SUBMITTER: Owsiany KM 

PROVIDER: S-EPMC9365248 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature