Insulin Prevents Hypercholesterolemia by Suppressing 12α-Hydroxylated Bile Acids.

ABSTRACT:

Background

The risk of cardiovascular disease in type 1 diabetes remains extremely high, despite marked advances in blood glucose control and even the widespread use of cholesterol synthesis inhibitors. Thus, a deeper understanding of insulin regulation of cholesterol metabolism, and its disruption in type 1 diabetes, could reveal better treatment strategies.

Methods

To define the mechanisms by which insulin controls plasma cholesterol levels, we knocked down the insulin receptor, FoxO1, and the key bile acid synthesis enzyme, CYP8B1. We measured bile acid composition, cholesterol absorption, and plasma cholesterol. In parallel, we measured markers of cholesterol absorption and synthesis in humans with type 1 diabetes treated with ezetimibe and simvastatin in a double-blind

SUBMITTER: Semova I 

PROVIDER: S-EPMC9365453 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature