The relationship between blood pressure and risk of renal cell carcinoma.

ABSTRACT:

Background

The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail.

Methods

Our study involved two prospective cohorts: the European Prospective Investigation into Cancer and Nutrition study and UK Biobank, including >700 000 participants and 1692 incident RCC cases. Risk analyses were conducted using flexible parametric survival models for DBP and SBP both separately as well as with mutuality adjustment and then adjustment for extended risk factors. We al

SUBMITTER: Alcala K 

PROVIDER: S-EPMC9365619 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature