How blood pressure predicts frailty transitions in older adults in a population-based cohort study: a multi-state transition model.

ABSTRACT:

Background

Low blood pressure (BP) is associated with frailty in older adults. Our aim was to explore how BP predicts transitions between frailty states.

Methods

We used data from the Lausanne cohort Lc65+, a population-based cohort of older adults randomly drawn from a population registry in Switzerland, in 2004, 2009 and 2014. BP was measured using a clinically validated oscillometric automated device and frailty was defined using Fried's phenotype, every 3 years. We used an illness-death discrete multi-state Markov model to estimate hazard ratios of forward and backward transitions between frailty states (outcome) in relation to BP categories (predictor of interest) with adjustment for sex, age and antihypertensive medication (other predictors).

Results

Among 4200

SUBMITTER: Anker D 

PROVIDER: S-EPMC9365628 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature