Dataset Information

Association between body mass index and oesophageal cancer mortality: a pooled analysis of prospective cohort studies with >800 000 individuals in the Asia Cohort Consortium.

ABSTRACT:

Background

The association between body mass index (BMI) and oesophageal cancer (OC) has been consistently negative among Asians, whereas different associations based on histological OC subtypes have been observed in Europeans and North Americans. We examined the association between BMI and OC mortality in the Asia Cohort Consortium.

Methods

We performed a pooled analysis to evaluate the association between BMI and OC mortality among 842 630 Asians from 18 cohort studies. Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs.

Results

A wide J-shaped association between BMI and overall OC mortality was observed. The OC mortality risk was increased for underweight (BMI <18.5 kg/m2: HR = 2.20, 95% CI 1.80-2.70) and extreme obesity (BMI ≥35 kg/m2: HR = 4.38, 95% CI 2.25-8.52) relative to the reference BMI (23-25 kg/m2). This association pattern was confirmed by several alternative analyses based on OC incidence and meta-analysis. A similar wide J-shaped association was observed in oesophageal squamous cell carcinoma (OSCC). Smoking and alcohol synergistically increased the OC mortality risk in underweight participants (HR = 6.96, 95% CI 4.54-10.67) relative to that in reference BMI participants not exposed to smoking and alcohol.

Conclusion

Extreme obesity and being underweight were associated with an OC mortality risk among Asians. OC mortality and BMI formed a wide J-shaped association mirrored by OSCC mortality. Although the effect of BMI on OSCC and oesophageal adenocarcinoma mortality can be different in Asians, further research based on a large case-control study is recommended.

SUBMITTER: Lee S

PROVIDER: S-EPMC9365631 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Association between body mass index and oesophageal cancer mortality: a pooled analysis of prospective cohort studies with >800 000 individuals in the Asia Cohort Consortium.

Lee Sangjun S Jang Jieun J Abe Sarah Krull SK Rahman Shafiur S Saito Eiko E Islam Rashedul R Gupta Prakash C PC Sawada Norie N Tamakoshi Akiko A Shu Xiao-Ou XO Koh Woon-Puay WP Sadakane Atsuko A Tsuji Ichiro I Kim Jeongseon J Oze Isao I Nagata Chisato C You San-Lin SL Shin Myung-Hee MH Pednekar Mangesh S MS Tsugane Shoichiro S Cai Hui H Yuan Jian-Min JM Wen Wanqing W Ozasa Kotaro K Matsuyama Sanae S Kanemura Seiki S Shin Aesun A Ito Hidemi H Wada Keiko K Sugawara Yumi Y Chen Chien-Jen CJ Ahn Yoon-Ok YO Chen Yu Y Ahsan Habibul H Boffetta Paolo P Chia Kee Seng KS Matsuo Keitaro K Qiao You-Lin YL Rothman Nathaniel N Zheng Wei W Inoue Manami M Kang Daehee D Park Sue K SK

International journal of epidemiology 20220801 4

<h4>Background</h4>The association between body mass index (BMI) and oesophageal cancer (OC) has been consistently negative among Asians, whereas different associations based on histological OC subtypes have been observed in Europeans and North Americans. We examined the association between BMI and OC mortality in the Asia Cohort Consortium.<h4>Methods</h4>We performed a pooled analysis to evaluate the association between BMI and OC mortality among 842 630 Asians from 18 cohort studies. Cox regr ...[more]

PMID: 35229874

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Dataset Information

Association between body mass index and oesophageal cancer mortality: a pooled analysis of prospective cohort studies with >800 000 individuals in the Asia Cohort Consortium.

Background

Methods

Results

Conclusion

Publications

Association between body mass index and oesophageal cancer mortality: a pooled analysis of prospective cohort studies with >800 000 individuals in the Asia Cohort Consortium.

Similar Datasets

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