The Effect of Capsaicin on Neuroinflammatory Mediators of Rosacea.

ABSTRACT:

Background

Rosacea is a chronic inflammatory skin disease with a pathophysiological mechanism that remains unclear. Recently, dysregulation of the sensory nerve system has been implicated in the development of this condition.

Objective

This study aimed to investigate the effect of capsaicin on neuroinflammatory mediators in rosacea. In addition, this study aimed to evaluate the attenuating effects of capsazepine, a transient receptor potential vanilloid type 1 (TRPV1) antagonist.

Methods

We obtained skin tissue from both rosacea patients and normal individuals for an in vivo study. In addition, normal human epidermal keratinocytes (NHEKs) were cultured, and treated with capsaicin and capsazepine for an in vitro study. Quantitative changes in neuroinflamm

SUBMITTER: Kim HB 

PROVIDER: S-EPMC9365654 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature