Role of Substance P in Regulating Micro-Milieu of Inflammation in Alopecia Areata.

ABSTRACT:

Background

Alopecia areata (AA) is an autoimmune disease characterized by chronic inflammation, the pathogenesis of which is unknown. Stress is believed to play a role; however, evidence remains insufficient. A recent study showed that substance P (SP) damaged hair follicles by causing neurogenic inflammation, activating perifollicular mast cells, and inducing keratinocyte apoptosis.

Objective

We aimed at studying the role of SP in AA pathogenesis. We investigated the SP levels in the lesional scalp tissues and serum. We also studied the effect of SP on the inflammatory response and hair growth in the outer root sheath (ORS) cells.

Methods

We compared the serum levels of SP in 58 AA patients and 28 healthy subjects. Then, we checked the expression of SP and SP recepto

SUBMITTER: Kim C 

PROVIDER: S-EPMC9365655 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature