Cortical feedback loops bind distributed representations of working memory.

ABSTRACT: Working memory-the brain's ability to internalize information and use it flexibly to guide behaviour-is an essential component of cognition. Although activity related to working memory has been observed in several brain regions^1-3, how neural populations actually represent working memory^4-7 and the mechanisms by which this activity is maintained^8-12 remain unclear^13-15. Here we describe the neural implementation of visual working memory in mice alternating between a delayed non-match-to-sample task and a simple discrimination task that does not require working memory but has identical stimulus, movement and reward statistics. Transient optogenetic inactivations revealed that distributed areas of the neocortex were required selectively for the mai

SUBMITTER: Voitov I 

PROVIDER: S-EPMC9365695 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature