Brown-fat-mediated tumour suppression by cold-altered global metabolism.

ABSTRACT: Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues^1-6. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis^2,7,8. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold and drugs instigates blood glucose uptake in adipocytes^4,5,9. However, the functional effects of the global metabolic changes associated with BAT activation on tumour growth are unclear. Here we show that exposure of tumour-bearing mice to cold conditions markedly inhibits the growth of various types of solid tumours, including clinically untreatable cancers such as pancreatic cancers. Mechanistically, cold-induced BAT activation substantially decreases blood gluco

SUBMITTER: Seki T 

PROVIDER: S-EPMC9365697 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature