A physical wiring diagram for the human immune system.

ABSTRACT: The human immune system is composed of a distributed network of cells circulating throughout the body, which must dynamically form physical associations and communicate using interactions between their cell-surface proteomes¹. Despite their therapeutic potential², our map of these surface interactions remains incomplete^3,4. Here, using a high-throughput surface receptor screening method, we systematically mapped the direct protein interactions across a recombinant library that encompasses most of the surface proteins that are detectable on human leukocytes. We independently validated and determined the biophysical parameters of each novel interaction, resulting in a high-confidence and quantitative view of the receptor wiring that connects human immune cell

SUBMITTER: Shilts J 

PROVIDER: S-EPMC9365698 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature