Spatially resolved clonal copy number alterations in benign and malignant tissue.

ABSTRACT: Defining the transition from benign to malignant tissue is fundamental to improving early diagnosis of cancer¹. Here we use a systematic approach to study spatial genome integrity in situ and describe previously unidentified clonal relationships. We used spatially resolved transcriptomics² to infer spatial copy number variations in >120,000 regions across multiple organs, in benign and malignant tissues. We demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate. Our results suggest a model for how genomic instability arises in histologically benign tissue that may represent early events in cancer evolution. We highlight the power of capturing th

SUBMITTER: Erickson A 

PROVIDER: S-EPMC9365699 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature