Peripheral gene interactions define interpretable clusters of core ASD genes in a network-based investigation of the omnigenic theory.

ABSTRACT: According to the recently proposed omnigenic theory, all expressed genes in a relevant tissue are contributing directly or indirectly to the manifestation of complex disorders such as autism. Thus, holistic approaches can be complementary in studying genetics of these complex disorders to focusing on a limited number of candidate genes. Gene interaction networks can be used for holistic studies of the omnigenic nature of autism. We used Louvain clustering on tissue-specific gene interaction networks and their subgraphs exclusively containing autism-related genes to study the effects of peripheral gene interactions. We observed that the autism gene clusters are significantly weaker connected to each other and the peripheral genes in non-neuronal tissues than in brain-related tissues. The bi

SUBMITTER: Fothi A 

PROVIDER: S-EPMC9365765 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature