Genetically-biased fertilization in APOBEC1 complementation factor (A1cf) mutant mice.

ABSTRACT: Meiosis, recombination, and gametogenesis normally ensure that gametes combine randomly. But in exceptional cases, fertilization depends on the genetics of gametes from both females and males. A key question is whether their non-random union results from factors intrinsic to oocytes and sperm, or from their interactions with conditions in the reproductive tracts. To address this question, we used in vitro fertilization (IVF) with a mutant and wild-type allele of the A1cf (APOBEC1 complementation factor) gene in mice that are otherwise genetically identical. We observed strong distortion in favor of mutant heterozygotes showing that bias depends on the genetics of oocyte and sperm, and that any environmental input is modest. To search for the potential mechanism of the 'biased fertilization

SUBMITTER: Hirose N 

PROVIDER: S-EPMC9365768 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature