Drinking hydrogen water improves photoreceptor structure and function in retinal degeneration 6 mice.

ABSTRACT: Retinitis pigmentosa (RP) is a genetically heterogeneous group of inherited retinal disorders involving the progressive dysfunction of photoreceptors and the retinal pigment epithelium, for which there is currently no treatment. The rd6 mouse is a natural model of autosomal recessive retinal degeneration. Given the known contributions of oxidative stress caused by reactive oxygen species (ROS) and selective inhibition of potent ROS peroxynitrite and OH·by H₂ gas we have previously demonstrated, we hypothesized that ingestion of H₂ water may delay the progression of photoreceptor death in rd6 mice. H₂ mice showed significantly higher retinal thickness as compared to controls on optical coherence tomography. Histopathological and morphometric analyses reveale

SUBMITTER: Igarashi T 

PROVIDER: S-EPMC9365798 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature