Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth.

ABSTRACT: Obsessive-compulsive symptoms (OCS) are common in school-aged children and predict the development of obsessive compulsive disorder (OCD). White-matter abnormalities have been described in OCD, but the white matter correlates of OCS in the developing brain are unclear. Some correlates of OCS (or a diagnosis of OCD) may reflect correlates of a transdiagnostic or even general psychopathology factor. We examined these questions in a large sample of typically developing youth (N = 1208), using a hierarchical analysis of fixel-based white matter measures in relation to OCS and general psychopathology. General psychopathology was associated with abnormalities in the posterior corpus callosum and forceps major in an age-dependent manner, suggesting altered maturation (specifically, hypermaturatio

SUBMITTER: Grazioplene RG 

PROVIDER: S-EPMC9365814 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature