Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer's disease.

ABSTRACT: The interplay among neuropathological mechanisms underlying Alzheimer's disease (AD), as neuroinflammation and amyloid-beta (Aβ), as well their impact on neuronal function remains elusive. A major gap in knowledge is the functional impact of neuroinflammation. The posterior cingulate cortex (PCC), as the most prominent site of amyloid pathology in AD, is a pivotal region to investigate the concomitant presence of pathophysiological mechanisms such as microglia activation, indexing neuroinflammation, and changes in task related activity. Here we used a dual PET approach to simultaneously study Aβ load and neuroinflammation (TSPO uptake marker), using ¹¹C-PiB and ¹¹C-PK11195 radiotracers, respectively and fMRI to study task related neural activation in an AD sample (n =

SUBMITTER: Canario N 

PROVIDER: S-EPMC9365841 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature