Evidence for histamine release in chronic inducible urticaria – A systematic review

ABSTRACT:

Background

Chronic inducible urticaria (CIndU) constitutes a group of nine different CIndUs in which pruritic wheals and/or angioedema occur after exposure to specific and definite triggers. Histamine released from activated and degranulating skin mast cells is held to play a key role in the pathogenesis of CIndU, but evidence to support this has, as of yet, not been reviewed systematically or in detail. We aim to characterize the role and relevance of histamine in CIndU.

Methods

We systematically searched 3 electronic databases (PubMed, Scopus, and Embase) for studies that reported increased serum or skin histamine concentration (direct evidence) or in vitro or ex vivo histamine release (indirect evidence) following trigger exposure.

Results

An initial total of

SUBMITTER: Kulthanan K 

PROVIDER: S-EPMC9365951 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature