Elevated Foxp3⁺ double-negative T cells are associated with disease progression during HIV infection.

ABSTRACT: Persistent immune activation, which occurs during the whole course of HIV infection, plays a pivotal role in CD4⁺ T cells depletion and AIDS progression. Furthermore, immune activation is a key factor that leads to impaired immune reconstitution after long-term effective antiretroviral therapy (ART), and is even responsible for the increased risk of developing non-AIDS co-morbidities. Therefore, it's imperative to identify an effective intervention targeting HIV-associated immune activation to improve disease management. Double negative T cells (DNT) were reported to provide immunosuppression during HIV infection, but the related mechanisms remained puzzled. Foxp3 endows Tregs with potent suppressive function to maintain immune homeostasis. However, whether DNT cells expressed F

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9365964 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature