Homeostatic regulation of extracellular signal-regulated kinase 1/2 activity and axonal K_v7.3 expression by prolonged blockade of hippocampal neuronal activity.

ABSTRACT: Homeostatic plasticity encompasses the mechanisms by which neurons stabilize their synaptic strength and excitability in response to prolonged and destabilizing changes in their network activity. Prolonged activity blockade leads to homeostatic scaling of action potential (AP) firing rate in hippocampal neurons in part by decreased activity of N-Methyl-D-Aspartate receptors and subsequent transcriptional down-regulation of potassium channel genes including KCNQ3 which encodes K_v7.3. Neuronal K_v7 channels are mostly heterotetramers of K_v7.2 and K_v7.3 subunits and are highly enriched at the axon initial segment (AIS) where their current potently inhibits repetitive and burst firing of APs. However, whether a decrease in K_v7.3 expr

SUBMITTER: Baculis BC 

PROVIDER: S-EPMC9366003 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature