Prediction of prognosis and pathologic grade in follicular lymphoma using ¹⁸F-FDG PET/CT.

ABSTRACT:

Purpose

We investigated the utility of a new baseline PET parameter expressing lesion dissemination and metabolic parameters for predicting progression-free survival (PFS) and pathologic grade in follicular lymphoma (FL).

Methods

The baseline ¹⁸F-FDG PET/CT images of 126 patients with grade 1-3A FL were retrospectively analyzed. A novel PET/CT parameter characterizing lesion dissemination, the distance between two lesions that were furthest apart (D _max), was calculated. The total metabolic tumor volume and total lesion glycolysis (TLG) were computed by using 41% of the maximum standardized uptake value (SUV_max) thresholding method.

Results

The 5-year PFS rate was 51.9% for all patients. In the multivariate analysis, high D</

SUBMITTER: Li H 

PROVIDER: S-EPMC9366037 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature