Microbial neuraminidase induces TLR4-dependent long-term immune priming in the brain.

ABSTRACT: Innate immune memory explains the plasticity of immune responses after repeated immune stimulation, leading to either enhanced or suppressed immune responses. This process has been extensively reported in peripheral immune cells and also, although modestly, in the brain. Here we explored two relevant aspects of brain immune priming: its persistence over time and its dependence on TLR receptors. For this purpose, we used an experimental paradigm consisting in applying two inflammatory stimuli three months apart. Wild type, toll-like receptor (TLR) 4 and TLR2 mutant strains were used. The priming stimulus was the intracerebroventricular injection of neuraminidase (an enzyme that is present in various pathogens able to provoke brain infections), which triggers an acute inflammatory process in

SUBMITTER: Fernandez-Arjona MDM 

PROVIDER: S-EPMC9366060 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature