Construction and validation of a glioblastoma prognostic model based on immune-related genes.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is a common malignant brain tumor with high mortality. It is urgently necessary to develop a new treatment because traditional approaches have plateaued.

Purpose

Here, we identified an immune-related gene (IRG)-based prognostic signature to comprehensively define the prognosis of GBM.

Methods

Glioblastoma samples were selected from the Chinese Glioma Genome Atlas (CGGA). We retrieved IRGs from the ImmPort data resource. Univariate Cox regression and LASSO Cox regression analyses were used to develop our predictive model. In addition, we constructed a predictive nomogram integrating the independent predictive factors to determine the one-, two-, and 3-year overall survival (OS) probabilities of individuals with GBM. Additionally

SUBMITTER: Huang K 

PROVIDER: S-EPMC9366078 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature