Comprehensive analysis of mycobacterium tuberculosis antigen-specific CD4⁺ T cell responses restricted by single HLA class II allotype in an individual.

ABSTRACT: Mycobacterium tuberculosis infection is generally asymptomatic as latent tuberculosis, but it is still known as the world's leading bacterial cause of death. The diagnosis of latent tuberculosis infection relies on the evidence of cellular immunity to mycobacterial antigens. Since the association between HLA class II and tuberculosis infection has been reported in several population groups, a detailed study on the CD4⁺ T cell response to major tuberculosis antigens is needed. To elucidate which HLA class II allotypes in an individual are preferentially used in tuberculosis, CD4⁺ T cells specific to TB10.4, Ag85b, ESAT-6, and CFP-10 of Mycobacterium tuberculosis antigens were analyzed comprehensively. A total of 33 healthy donors were analyzed by ex vi

SUBMITTER: Lee YH 

PROVIDER: S-EPMC9366214 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature