The Role of Rituximab in Primary Focal Segmental Glomerular Sclerosis of the Adult

ABSTRACT:

Introduction

Primary focal segmental glomerular sclerosis (FSGS) is a rare, likely immune-mediated disease. Rituximab (RTX) may play a role in management, although data in adults are scanty.

Methods

We collected cases of RTX-treated primary FSGS within the Italian Society of Nephrology Immunopathology Working Group and explored response rate (24-hour proteinuria <3.5 g and <50% compared with baseline, stable estimated glomerular filtration rate).

Results

A total of 31 patients were followed for at least 12 months; further follow-up (median 17 months, interquartile range [IQR] 15–33.5) was available for 11. At first RTX administration, median creatinine and 24-hour proteinuria were 1.17 mg/dl (IQR 0.83–1.62) and 5.2 g (IQR 3.3–8.81), respectively. Response rate at

SUBMITTER: Tedesco M 

PROVIDER: S-EPMC9366368 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature