Multidimensional molecular measurements-environment interaction analysis for disease outcomes.

ABSTRACT: Multiple types of molecular (genetic, genomic, epigenetic, etc.) measurements, environmental risk factors, and their interactions have been found to contribute to the outcomes and phenotypes of complex diseases. In each of the previous studies, only the interactions between one type of molecular measurement and environmental risk factors have been analyzed. In recent biomedical studies, multidimensional profiling, in which data from multiple types of molecular measurements are collected from the same subjects, is becoming popular. A myriad of recent studies have shown that collectively analyzing multiple types of molecular measurements is not only biologically sensible but also leads to improved estimation and prediction. In this study, we conduct an M-E interaction analysis, with M standi

SUBMITTER: Xu Y 

PROVIDER: S-EPMC9366385 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature