Evaluation of the Effect of Macrocyclic Ring Size on [²⁰³Pb]Pb(II) Complex Stability in Pyridyl-Containing Chelators.

ABSTRACT: As an element-equivalent theranostic pair, lead-203 (²⁰³Pb, 100% EC, half-life = 51.92 h) and lead-212 (²¹²Pb, 100% β^-, half-life = 10.64 h), through the emission of γ rays and an α particle in its decay chain, respectively, can aid in the development of personalized targeted radionuclide treatment for advanced and currently untreatable cancers. With these isotopes currently being used in clinical trials, an understanding of the relationship between the chelator structure, ability to incorporate the radiometal, and metal-complex stability is needed to help design appropriate chelators for clinical use. Herein, we report an investigation into the effect of ring size in macrocyclic chelators where pyridine, an intermediate Lewis base, acts as an electron dono

SUBMITTER: McNeil BL 

PROVIDER: S-EPMC9366509 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature