Identification of promising nutraceuticals against filarial immune-modulatory proteins: insights from in silico and ex vivo studies.

ABSTRACT: Lymphatic filariasis is a neglected tropical disease affecting over 863 million people in 47 countries of the world. The anti-filarial drugs, diethylcarbamazine, albendazole, and ivermectin, are effective only at the larval stages and have proven completely ineffective as adulticides. Besides this, a long-term use of these drugs is associated with several side effects including drug toxicity. Nutraceuticals have emerged as better alternatives for long term treatments due to their safety and lesser side effects. In the present work, we have used drug docking analysis and molecular dynamics simulation approaches to explore the effect of anti-inflammatory nutraceuticals against the immune-modulatory proteins of filarial worms. The filarial proteins enolase, ES-62 precursor, serpin, and cystat

SUBMITTER: Kumar V 

PROVIDER: S-EPMC9366595 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature