Risk of COPD exacerbation is increased by poor sleep quality and modified by social adversity.

ABSTRACT:

Study objectives

Sleep is an important dimension in the care of chronic obstructive pulmonary disease (COPD), but its relevance to exacerbations is unclear. We wanted to assess whether sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) is associated with an increased risk of COPD exacerbations and does this differ by socio-environmental exposures.

Methods

We included 1647 current and former smokers with spirometrically confirmed COPD from the SPIROMICS cohort. We assessed incidence rate ratios for exacerbation using zero-inflated negative binomial regression adjusting for demographics, medical comorbidities, and multiple metrics of disease severity, including respiratory medications, airflow obstruction, and symptom burden. Our final model adjusted for so

SUBMITTER: Baugh A 

PROVIDER: S-EPMC9366643 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature