Modulation of neural co-firing to enhance network transmission and improve motor function after stroke.

ABSTRACT: Stroke is a leading cause of disability. While neurotechnology has shown promise for improving upper limb recovery after stroke, efficacy in clinical trials has been variable. Our central thesis is that to improve clinical translation, we need to develop a common neurophysiological framework for understanding how neurotechnology alters network activity. Our perspective discusses principles for how motor networks, both healthy and those recovering from stroke, subserve reach-to-grasp movements. We focus on neural processing at the resolution of single movements, the timescale at which neurotechnologies are applied, and discuss how this activity might drive long-term plasticity. We propose that future studies should focus on cross-area communication and bridging our understanding of timescal

SUBMITTER: Ganguly K 

PROVIDER: S-EPMC9366919 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature