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ABSTRACT: Background
To report the burden of cancers attributable to high fasting plasma glucose (HFPG) by sex, age, location, cancer type and Socio-demographic Index (SDI) over the period 1990 to 2019 for 204 countries and territories.Methods
Using the Comparative Risk Assessment approach of Global Burden of Disease (GBD) study 2019, the burden of cancers attributable to HFPG was reported in 1990 and 2019.Results
Globally, in 2019 there were an estimated 419.3 thousand cancer deaths (95% UI: 115.7 to 848.5) and 8.6 million cancer DALYs (2.4 to 17.6) attributable to HFPG. By sex, 4.6 (1.1 to 9.9) and 4.0 (1.1 to 8.4) million global cancer DALYs were attributable to HFPG in men and women, respectively. The global age-standardized death and DALY rates of cancers attributable to HFPG (per 100,000) have increased by 27.8% (20.5 to 38.7%) and 24.5% (16.4 to 35.6%), respectively, since 1990. High-income North America (9.5 [2.7 to 18.8]) and Eastern Sub-Saharan Africa (2.0 [0.5 to 4.2]) had the highest and lowest regional age-standardized death rates, respectively, for cancers attributable to HFPG. In 2019, the global number of attributable cancer DALYs were highest in 65-69 age group. Moreover, there was an overall positive association between SDI and the regional age-standardized DALY rate for HFPG-attributable cancers.Conclusions
HFPG was associated with more burden in 2019. Preventive programs for diabetes and screening of individuals with diabetes for cancers, especially in older males living in developed countries, are required to arrest the large increases in HFPG-attributable cancers.
SUBMITTER: Safiri S
PROVIDER: S-EPMC9366927 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Safiri Saeid S Nejadghaderi Seyed Aria SA Karamzad Nahid N Kaufman Jay S JS Carson-Chahhoud Kristin K Bragazzi Nicola Luigi NL Sullman Mark J M MJM Beyranvand Mohammad Reza MR Mansournia Mohammad Ali MA Almasi-Hashiani Amir A Collins Gary S GS Kolahi Ali-Asghar AA
Frontiers in endocrinology 20220719
<h4>Background</h4>To report the burden of cancers attributable to high fasting plasma glucose (HFPG) by sex, age, location, cancer type and Socio-demographic Index (SDI) over the period 1990 to 2019 for 204 countries and territories.<h4>Methods</h4>Using the Comparative Risk Assessment approach of Global Burden of Disease (GBD) study 2019, the burden of cancers attributable to HFPG was reported in 1990 and 2019.<h4>Results</h4>Globally, in 2019 there were an estimated 419.3 thousand cancer deat ...[more]