Exploring the Effect of Glycerol and Hydrochloric Acid on Mesoporous Silica Synthesis: Application in Insulin Loading.

ABSTRACT: Mesoporous silica (MPS), a carrier for active pharmaceutical ingredients, has a wide range of particle and pore morphology. A thorough understanding of ingredients used in MPS synthesis is an important prerequisite for optimizing its physicochemical characteristics. The present study aimed to evaluate the effect of glycerol and hydrochloric acid on the characteristics of synthesized MPS. Ordered MPS materials were synthesized using the pluronic P123 template and tetraethyl orthosilicate (TEOS) precursor. A three-level factorial design was employed to study the interaction between glycerol and hydrochloric acid. The optimized MPS particles were reasonably uniform in shape (short and rod-shaped) and < 1 μm in size with a smooth surface morphology. The nitrogen adsorption-desorption analysis

SUBMITTER: Oo MK 

PROVIDER: S-EPMC9366981 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature