Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups.

ABSTRACT:

Background

Interleukin 6 (IL-6) signaling is being investigated as a therapeutic target for atherosclerotic cardiovascular disease (CVD). While changes in circulating high-sensitivity C-reactive protein (hsCRP) are used as a marker of IL-6 signaling, it is not known whether there is effect heterogeneity in relation to baseline hsCRP levels or other cardiovascular risk factors. The aim of this study was to explore the association of genetically predicted IL-6 signaling with CVD risk across populations stratified by baseline hsCRP levels and cardiovascular risk factors.

Methods

Among 397,060 White British UK Biobank participants without known CVD at baseline, we calculated a genetic risk score for IL-6 receptor (IL-6R)-mediated signaling, composed of 26 variants at the IL6R ge

SUBMITTER: Georgakis MK 

PROVIDER: S-EPMC9367072 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature