The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice.

ABSTRACT:

Background

Cordia myxa L. (Boraginaceae) is widely distributed in tropical regions and it's fruits, leaves and stem bark have been utilized in folk medicine for treating trypanosomiasis caused by Trypanosoma cruzi. A population-based study showed that T. cruzi infection is associated with cognitive impairments. Therefore, if C. myxa has ameliorating activities on cognitive function, it would be useful for both T. cruzi infection and cognitive impairments.

Methods

In this study, we evaluated the effects of an ethanol extract of leaves of C. myxa (ELCM) on memory impairments and sensorimotor gating deficits in mice. The phosphorylation level of protein was observed by the Western blot analysis.

Results

The administration of ELCM significantly attenuated scopolamine-indu

SUBMITTER: Kendir G 

PROVIDER: S-EPMC9367120 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature