Mutational Landscape of CEBPA in Mexican Pediatric Acute Myeloid Leukemia Patients: Prognostic Implications.

ABSTRACT:

Background

In Mexico, the incidence of acute myeloid leukemia (AML) has increased in the last few years. Mortality is higher than in developed countries, even though the same chemotherapy protocols are used. CCAAT Enhancer Binding Protein Alpha (CEBPA) mutations are recurrent in AML, influence prognosis, and help to define treatment strategies. CEBPA mutational profiles and their clinical implications have not been evaluated in Mexican pediatric AML patients.

Aim of the study

To identify the mutational landscape of the CEBPA gene in pediatric patients with de novo AML and assess its influence on clinical features and overall survival (OS).

Materials and methods

DNA was extracted from bone marrow aspirates at diagnosis. Targeted massive para

SUBMITTER: Molina Garay C 

PROVIDER: S-EPMC9367218 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature