Human Malignant Rhabdoid Tumor Antigens as Biomarkers and Potential Therapeutic Targets.

ABSTRACT:

Introduction

Atypical teratoid rhabdoid tumor (ATRT) is a lethal type of malignant rhabdoid tumor in the brain, seen mostly in children under two years old. ATRT is mainly linked to the biallelic inactivation of the SMARCB1 gene. To understand the deadly characteristics of ATRT and develop novel diagnostic and immunotherapy strategies for the treatment of ATRT, this study investigated tumor antigens, such as alpha-fetoprotein (AFP), mucin-16 (MUC16/CA125), and osteopontin (OPN), and extracellular matrix modulators, such as matrix metalloproteinases (MMPs), in different human malignant rhabdoid tumor cell lines. In addition, the roles of MMPs were also examined.

Materials and methods

Five human cell lines were chosen for this study, including two ATRT cell lines, CHLA-02-ATRT

SUBMITTER: Hua T 

PROVIDER: S-EPMC9367328 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature