Understanding Metabolic Alterations in Cancer Cachexia through the Lens of Exercise Physiology.

ABSTRACT: Cancer cachexia is one of the leading causes of mortality for late-stage cancer patients. One of its key characteristics is abnormal metabolism and loss of metabolic flexibility, i.e., loss of ability to switch between use of fats and carbohydrates as needed. Here, it is hypothesized that late-stage systemic cancer creates a chronic resource drain on the body that may result in the same metabolic adaptations that occur during intense endurance exercise, activating some of the same mechanisms of nutrient consumption that are supposed to be transient during strenuous physical activity. This hypothesis is evaluated by creating a mathematical model that characterizes the relationships between increased exercise intensity and carbohydrate and fat oxidation. The model is parametrized using publi

SUBMITTER: Kareva I 

PROVIDER: S-EPMC9367382 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature