Human Leucocyte Antigens as Prognostic Markers in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Background

The induction and regulation of immune responses depend on human leucocyte antigen (HLA) molecules that present peptides derived from mutated neoantigens or tumor-associated antigens to cytotoxic T cells. The natural variation of HLA molecules might differ between tumor patients and the normal population. Thus, there might be associations between the frequencies of HLA alleles and the survival of tumor patients.

Methods

This issue was studied in a cohort of 84 patients with head and neck squamous cell carcinomas (HNSCCs) of different localizations. The cohort was followed up for more than 10 years. HLA-A/B/C CTS-PCR-SSP typing at 1 field level from blood samples was performed, and the results were correlated with survival.

Results

HLA-A*02 was the most prev

SUBMITTER: Dyckhoff G 

PROVIDER: S-EPMC9367389 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature